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Protocol for the Generation of Human Pluripotent Reporter Cell Lines Using CRISPR/Cas9

Reporter cell lines based on human pluripotent stem cells (hPSCs) are highly desirable for studying differentiation, lineage tracing, and target cell selection. However, several technical bottlenecks, such as DNA transduction, low homology recombination rate (HDR), and single-cell cloning, have made...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:STAR Protoc
Prif Awduron: Zhong, Aaron, Li, Mu, Zhou, Ting
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566848/
https://ncbi.nlm.nih.gov/pubmed/33073252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2020.100052
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