Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury

We determined that renal proximal tubular (PT) NF-κB essential modulator (NEMO) plays a direct and critical role in ischemic acute kidney injury (AKI) using mice lacking renal PT NEMO and by targeted renal PT NEMO inhibition with mesoscale nanoparticle–encapsulated NEMO binding peptide (NBP MNP). We...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Han, Sang Jun, Williams, Ryan M., Kim, Mihwa, Heller, Daniel A., D’Agati, Vivette, Schmidt-Supprian, Marc, Lee, H. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566738/
https://ncbi.nlm.nih.gov/pubmed/32941183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139246
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