Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury

We determined that renal proximal tubular (PT) NF-κB essential modulator (NEMO) plays a direct and critical role in ischemic acute kidney injury (AKI) using mice lacking renal PT NEMO and by targeted renal PT NEMO inhibition with mesoscale nanoparticle–encapsulated NEMO binding peptide (NBP MNP). We...

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Publicat a:JCI Insight
Autors principals: Han, Sang Jun, Williams, Ryan M., Kim, Mihwa, Heller, Daniel A., D’Agati, Vivette, Schmidt-Supprian, Marc, Lee, H. Thomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566738/
https://ncbi.nlm.nih.gov/pubmed/32941183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139246
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