Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and limits poliovirus spread. Accordingly, vaccination with OPV is the primary strategy used to end the circulation of all poliov...

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Bibliografiske detaljer
Udgivet i:Cell Host Microbe
Main Authors: Yeh, Ming Te, Bujaki, Erika, Dolan, Patrick T., Smith, Matthew, Wahid, Rahnuma, Konz, John, Weiner, Amy J., Bandyopadhyay, Ananda S., Van Damme, Pierre, De Coster, Ilse, Revets, Hilde, Macadam, Andrew, Andino, Raul
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566161/
https://ncbi.nlm.nih.gov/pubmed/32330425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.04.003
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