Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and limits poliovirus spread. Accordingly, vaccination with OPV is the primary strategy used to end the circulation of all poliov...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Yeh, Ming Te, Bujaki, Erika, Dolan, Patrick T., Smith, Matthew, Wahid, Rahnuma, Konz, John, Weiner, Amy J., Bandyopadhyay, Ananda S., Van Damme, Pierre, De Coster, Ilse, Revets, Hilde, Macadam, Andrew, Andino, Raul
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566161/
https://ncbi.nlm.nih.gov/pubmed/32330425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.04.003
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