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Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and limits poliovirus spread. Accordingly, vaccination with OPV is the primary strategy used to end the circulation of all poliov...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Host Microbe
Hauptverfasser: Yeh, Ming Te, Bujaki, Erika, Dolan, Patrick T., Smith, Matthew, Wahid, Rahnuma, Konz, John, Weiner, Amy J., Bandyopadhyay, Ananda S., Van Damme, Pierre, De Coster, Ilse, Revets, Hilde, Macadam, Andrew, Andino, Raul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566161/
https://ncbi.nlm.nih.gov/pubmed/32330425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.04.003
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