HIV-1 Lethality and Loss of Env Protein Expression Induced by Single Synonymous Substitutions in the Virus Genome Intronic-Splicing Silencer

Synonymous genome recoding has been widely used to study different aspects of virus biology. Codon usage affects the temporal regulation of viral gene expression. In this study, we performed synonymous codon mutagenesis to investigate whether codon usage affected HIV-1 Env protein expression and vir...

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Veröffentlicht in:J Virol
Hauptverfasser: Jordan-Paiz, Ana, Nevot, Maria, Lamkiewicz, Kevin, Lataretu, Marie, Franco, Sandra, Marz, Manja, Martinez, Miguel Angel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565636/
https://ncbi.nlm.nih.gov/pubmed/32817222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01108-20
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