HIV-1 Lethality and Loss of Env Protein Expression Induced by Single Synonymous Substitutions in the Virus Genome Intronic-Splicing Silencer

Synonymous genome recoding has been widely used to study different aspects of virus biology. Codon usage affects the temporal regulation of viral gene expression. In this study, we performed synonymous codon mutagenesis to investigate whether codon usage affected HIV-1 Env protein expression and vir...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Jordan-Paiz, Ana, Nevot, Maria, Lamkiewicz, Kevin, Lataretu, Marie, Franco, Sandra, Marz, Manja, Martinez, Miguel Angel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565636/
https://ncbi.nlm.nih.gov/pubmed/32817222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01108-20
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