Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling

Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A to PPP2R5E). While APOBEC3 antagonism is the canonical function of HIV-1 Vif, this viral accessory protein is also k...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Salamango, Daniel J., McCann, Jennifer L., Demir, Özlem, Becker, Jordan T., Wang, Jiayi, Lingappa, Jairam R., Temiz, Nuri A., Brown, William L., Amaro, Rommie E., Harris, Reuben S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565612/
https://ncbi.nlm.nih.gov/pubmed/32847850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00631-20
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