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Origin of Genome Instability and Determinants of Mutational Landscape in Cancer Cells

Genome instability is a crucial and early event associated with an increased predisposition to tumor formation. In the absence of any exogenous agent, a single human cell is subjected to about 70,000 DNA lesions each day. It has now been shown that physiological cellular processes including DNA tran...

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Dettagli Bibliografici
Pubblicato in:Genes (Basel)
Autori principali: Mehrotra, Sonam, Mittra, Indraneel
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7563369/
https://ncbi.nlm.nih.gov/pubmed/32967144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11091101
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