Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection

Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation (AF), however, precise correction of the associated mutat...

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Publicat a:Stem Cell Reports
Autors principals: Sumer, Simon Alexander, Hoffmann, Sandra, Laue, Svenja, Campbell, Birgit, Raedecke, Kristin, Frajs, Viktoria, Clauss, Sebastian, Kääb, Stefan, Janssen, Johannes W.G., Jauch, Anna, Laugwitz, Karl-Ludwig, Dorn, Tatjana, Moretti, Alessandra, Rappold, Gudrun A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7562944/
https://ncbi.nlm.nih.gov/pubmed/32976766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.08.015
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