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Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection

Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation (AF), however, precise correction of the associated mutat...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Stem Cell Reports
Κύριοι συγγραφείς: Sumer, Simon Alexander, Hoffmann, Sandra, Laue, Svenja, Campbell, Birgit, Raedecke, Kristin, Frajs, Viktoria, Clauss, Sebastian, Kääb, Stefan, Janssen, Johannes W.G., Jauch, Anna, Laugwitz, Karl-Ludwig, Dorn, Tatjana, Moretti, Alessandra, Rappold, Gudrun A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2020
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7562944/
https://ncbi.nlm.nih.gov/pubmed/32976766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.08.015
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