Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection

Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation (AF), however, precise correction of the associated mutat...

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Bibliografski detalji
Izdano u:Stem Cell Reports
Glavni autori: Sumer, Simon Alexander, Hoffmann, Sandra, Laue, Svenja, Campbell, Birgit, Raedecke, Kristin, Frajs, Viktoria, Clauss, Sebastian, Kääb, Stefan, Janssen, Johannes W.G., Jauch, Anna, Laugwitz, Karl-Ludwig, Dorn, Tatjana, Moretti, Alessandra, Rappold, Gudrun A.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
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Resource
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7562944/
https://ncbi.nlm.nih.gov/pubmed/32976766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.08.015
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