The Shigella Type III Secretion Effector IpaH4.5 Targets NLRP3 to Activate Inflammasome Signaling

Activation of the NLRP3 inflammasome requires the expression of NLRP3, which is strictly regulated by its capacity to directly recognize microbial-derived substances. Even though the involvement of caspase-1 activation in macrophages via NLRP3 and NLRC4 has been discovered, the accurate mechanisms b...

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Detalles Bibliográficos
Publicado en:Front Cell Infect Microbiol
Autores principales: Wang, Xiaolin, Sun, Jin, Wan, Luming, Yang, Xiaopan, Lin, Haotian, Zhang, Yanhong, He, Xiang, Zhong, Hui, Guan, Kai, Min, Min, Sun, Zhenxue, Yang, Xiaoli, Wang, Bin, Dong, Mingxin, Wei, Congwen
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561375/
https://ncbi.nlm.nih.gov/pubmed/33117724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.511798
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