Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages

When nucleotide-binding oligomerization domain–like receptors (NLRs) sense cytosolic-invading bacteria, they induce the formation of inflammasomes and initiate an innate immune response. In quiescent cells, inflammasome activity is tightly regulated to prevent excess inflammation and cell death. Man...

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Hlavní autoři: Suzuki, Shiho, Mimuro, Hitomi, Kim, Minsoo, Ogawa, Michinaga, Ashida, Hiroshi, Toyotome, Takahito, Franchi, Luigi, Suzuki, Masato, Sanada, Takahito, Suzuki, Toshihiko, Tsutsui, Hiroko, Núñez, Gabriel, Sasakawa, Chihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210038/
https://ncbi.nlm.nih.gov/pubmed/25246571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324021111
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