The Shigella Type III Secretion Effector IpaH4.5 Targets NLRP3 to Activate Inflammasome Signaling

Activation of the NLRP3 inflammasome requires the expression of NLRP3, which is strictly regulated by its capacity to directly recognize microbial-derived substances. Even though the involvement of caspase-1 activation in macrophages via NLRP3 and NLRC4 has been discovered, the accurate mechanisms b...

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Bibliografiske detaljer
Udgivet i:Front Cell Infect Microbiol
Main Authors: Wang, Xiaolin, Sun, Jin, Wan, Luming, Yang, Xiaopan, Lin, Haotian, Zhang, Yanhong, He, Xiang, Zhong, Hui, Guan, Kai, Min, Min, Sun, Zhenxue, Yang, Xiaoli, Wang, Bin, Dong, Mingxin, Wei, Congwen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Cellular and Infection Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561375/
https://ncbi.nlm.nih.gov/pubmed/33117724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.511798
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