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LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes
Genetic variation in LRRK2 associates with the susceptibility to Parkinson's disease, Crohn's disease, and mycobacteria infection. High expression of LRRK2 and its substrate Rab10 occurs in phagocytic cells in the immune system. In mouse and human primary macrophages, dendritic cells, and...
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| Vydáno v: | EMBO J |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7560233/ https://ncbi.nlm.nih.gov/pubmed/32853409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104862 |
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