LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Human genetic studies implicate LRRK2 and RAB7L1 in susceptibility to Parkinson disease (PD). These two genes function in the same pathway, as knockout of Rab7L1 results in phenotypes similar to LRRK2 knockout, and studies in cells and model organisms demonstrate LRRK2 and Rab7L1 interact in the end...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Liu, Zhiyong, Bryant, Nicole, Kumaran, Ravindran, Beilina, Alexandra, Abeliovich, Asa, Cookson, Mark R, West, Andrew B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886198/
https://ncbi.nlm.nih.gov/pubmed/29177506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx410
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