The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking

The link between cholesterol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationship relates to Alzheimer's disease (AD) pathogenesis, is still unknown. Cellular cholesterol levels are regulated through crosstalk between the plasma membrane (PM), where most ce...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Montesinos, Jorge, Pera, Marta, Larrea, Delfina, Guardia‐Laguarta, Cristina, Agrawal, Rishi R, Velasco, Kevin R, Yun, Taekyung D, Stavrovskaya, Irina G, Xu, Yimeng, Koo, So Yeon, Snead, Amanda M, Sproul, Andrew A, Area‐Gomez, Estela
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560219/
https://ncbi.nlm.nih.gov/pubmed/32865299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103791
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