MILD CHOLESTEROL DEPLETION REDUCES AMYLOID-β PRODUCTION BY IMPAIRING APP TRAFFICKING TO THE CELL SURFACE

It has been suggested that cellular cholesterol levels can modulate the metabolism of the amyloid precursor protein (APP) but the underlying mechanism remains controversial. In the current study, we investigate in detail the relationship between cholesterol reduction, APP processing and γ-secretase...

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Detalhes bibliográficos
Main Authors: Guardia-Laguarta, Cristina, Coma, Mireia, Pera, Marta, Clarimón, Jordi, Sereno, Lidia, Agulló, José M., Molina-Porcel, Laura, Gallardo, Eduard, Deng, Amy, Berezovska, Oksana, Hyman, Bradley T., Blesa, Rafael, Gómez-Isla, Teresa, Lleó, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741735/
https://ncbi.nlm.nih.gov/pubmed/19457132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06126.x
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