TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma

BACKGROUND: Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting the PI3K pathway have been underwhelming and the development...

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Bibliografische gegevens
Gepubliceerd in:J Exp Clin Cancer Res
Hoofdauteurs: Ruicci, Kara M., Meens, Jalna, Plantinga, Paul, Stecho, William, Pinto, Nicole, Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Boutros, Paul C., Ailles, Laurie, Nichols, Anthony C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559997/
https://ncbi.nlm.nih.gov/pubmed/33059733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01713-9
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