TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma

BACKGROUND: Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting the PI3K pathway have been underwhelming and the development...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Ruicci, Kara M., Meens, Jalna, Plantinga, Paul, Stecho, William, Pinto, Nicole, Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Boutros, Paul C., Ailles, Laurie, Nichols, Anthony C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559997/
https://ncbi.nlm.nih.gov/pubmed/33059733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01713-9
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