Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition

Phosphoinositide 3‐kinase (PI3K) is aberrantly activated in head and neck squamous cell carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving Akt signaling, leading to cell survival and proliferation. Phosphorylation of Akt Thr308 by PI3K‐PDK1 and Akt Ser473 by mammalian target of...

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Dades bibliogràfiques
Publicat a:Mol Oncol
Autors principals: Ruicci, Kara M., Plantinga, Paul, Pinto, Nicole, Khan, Mohammed I., Stecho, William, Dhaliwal, Sandeep S., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Nichols, Anthony C.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763779/
https://ncbi.nlm.nih.gov/pubmed/31393061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12558
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