Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition

Phosphoinositide 3‐kinase (PI3K) is aberrantly activated in head and neck squamous cell carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving Akt signaling, leading to cell survival and proliferation. Phosphorylation of Akt Thr308 by PI3K‐PDK1 and Akt Ser473 by mammalian target of...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Ruicci, Kara M., Plantinga, Paul, Pinto, Nicole, Khan, Mohammed I., Stecho, William, Dhaliwal, Sandeep S., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Nichols, Anthony C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763779/
https://ncbi.nlm.nih.gov/pubmed/31393061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12558
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