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Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors
The X-ray structure of the catalytic domain of the EphA3 tyrosine kinase in complex with a previously reported type II inhibitor was used to design two novel quinoxaline derivatives, inspired by kinase inhibitors that have reached clinical development. These two new compounds were characterized by a...
Tallennettuna:
| Julkaisussa: | RSC Med Chem |
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| Päätekijät: | , , , , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Royal Society of Chemistry
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7557569/ https://ncbi.nlm.nih.gov/pubmed/33479666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00049c |
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