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Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules
[Image: see text] We analyze 20 crystal structures of complexes between the CBP bromodomain and small-molecule ligands that belong to eight different chemotypes identified by docking. The binding motif of the moiety that mimics the natural ligand (acetylated side chain of lysine) at the bottom of th...
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| Publicado en: | ACS Med Chem Lett |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical
Society
2018
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6142054/ https://ncbi.nlm.nih.gov/pubmed/30258543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00286 |
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