Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors

The X-ray structure of the catalytic domain of the EphA3 tyrosine kinase in complex with a previously reported type II inhibitor was used to design two novel quinoxaline derivatives, inspired by kinase inhibitors that have reached clinical development. These two new compounds were characterized by a...

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Veröffentlicht in:RSC Med Chem
Hauptverfasser: Unzue, Andrea, Jessen-Trefzer, Claudia, Spiliotopoulos, Dimitrios, Gaudio, Eugenio, Tarantelli, Chiara, Dong, Jing, Zhao, Hongtao, Pachmayr, Johanna, Zahler, Stefan, Bernasconi, Elena, Sartori, Giulio, Cascione, Luciano, Bertoni, Francesco, Śledź, Paweł, Caflisch, Amedeo, Nevado, Cristina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2020
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557569/
https://ncbi.nlm.nih.gov/pubmed/33479666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00049c
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