The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

BACKGROUND: Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases, such as frontotemporal lobar degeneration with TDP-43 (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). However, the role of...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Lee, Shinrye, Kim, Seyeon, Kang, Ha-Young, Lim, Hye Ryeong, Kwon, Younghwi, Jo, Myungjin, Jeon, Yu-Mi, Kim, Sang Ryong, Kim, Kiyoung, Ha, Chang Man, Lee, Seongsoo, Kim, Hyung-Jun
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556969/
https://ncbi.nlm.nih.gov/pubmed/33054766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01963-6
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