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The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies

TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 aggregates in the central nervous system is a common feature of many neurodegenerative diseases, such as amyotrophic lateral sclerosis (A...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Jo, Myungjin, Lee, Shinrye, Jeon, Yu-Mi, Kim, Seyeon, Kwon, Younghwi, Kim, Hyung-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080625/
https://ncbi.nlm.nih.gov/pubmed/33051572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-020-00513-7
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