The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs

Tyrosine kinases have been implicated in promoting tumorigenesis of several human cancers. Exploiting these vulnerabilities has been shown to be an effective anti-tumor strategy as demonstrated for example by the Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, for treatment of various blood cance...

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Publicado en:Haematologica
Main Authors: Soncini, Debora, Orecchioni, Stefania, Ruberti, Samantha, Minetto, Paola, Martinuzzi, Claudia, Agnelli, Luca, Todoerti, Katia, Cagnetta, Antonia, Miglino, Maurizio, Clavio, Marino, Contini, Paola, Varaldo, Riccardo, Bergamaschi, Micaela, Guolo, Fabio, Passalacqua, Mario, Nencioni, Alessio, Monacelli, Fiammetta, Gobbi, Marco, Neri, Antonino, Abbadessa, Giovanni, Eathiraj, Sudharshan, Schwartz, Brian, Bertolini, Francesco, Lemoli, Roberto M., Cea, Michele
Formato: Artigo
Idioma:Inglês
Publicado: Fondazione Ferrata Storti 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556675/
https://ncbi.nlm.nih.gov/pubmed/33054082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.224956
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