Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

Tissue factor (TF) is highly expressed in sub-endothelial tissue. The extracellular allosteric disulfide bond Cys186–Cys209 of human TF shows high evolutionary conservation and in vitro evidence suggests that it significantly contributes to TF procoagulant activity. To investigate the role of this a...

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Bibliografiset tiedot
Julkaisussa:Haematologica
Päätekijät: Sluka, Susanna H. M., Stämpfli, Simon F., Akhmedov, Alexander, Rodewald, Tanja Klein, Sanz-Moreno, Adrián, Horsch, Marion, Grest, Paula, Rothmeier, Andrea S., Rathkolb, Birgit, Schrewe, Anja, Beckers, Johannes, Neff, Frauke, Wolf, Eckhard, Camici, Giovanni G., Fuchs, Helmut, Durner, Valerie Gailus, de Angelis, Martin Hrabě, Lüscher, Thomas F., Ruf, Wolfram, Tanner, Felix C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Fondazione Ferrata Storti 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556672/
https://ncbi.nlm.nih.gov/pubmed/33054088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.218818
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