Alternatively Spliced Tissue Factor Is Not Sufficient for Embryonic Development

Tissue factor (TF) triggers blood coagulation and is translated from two mRNA splice isoforms, encoding membrane-anchored full-length TF (flTF) and soluble alternatively-spliced TF (asTF). The complete knockout of TF in mice causes embryonic lethality associated with failure of the yolk sac vasculat...

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Main Authors: Sluka, Susanna H. M., Akhmedov, Alexander, Vogel, Johannes, Unruh, Dusten, Bogdanov, Vladimir Y., Camici, Giovanni G., Lüscher, Thomas F., Ruf, Wolfram, Tanner, Felix C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039448/
https://ncbi.nlm.nih.gov/pubmed/24879059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097793
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