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The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress

The conserved O-GlcNAc transferase OGT O-GlcNAcylates serine and threonine residues of intracellular proteins to regulate their function. OGT is required for viability in mammalian cells, but its specific roles in cellular physiology are poorly understood. Here we describe a conserved requirement fo...

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Publicat a:PLoS Genet
Autors principals: Urso, Sarel J., Comly, Marcella, Hanover, John A., Lamitina, Todd
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556452/
https://ncbi.nlm.nih.gov/pubmed/33006972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008821
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