Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite

Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly studied using LC-MS based approaches. However, metabolite quantities isolated...

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Vydáno v:Front Pharmacol
Hlavní autoři: Honrao, Chandrashekhar, Ma, Xiaoyu, Kulkarni, Shashank, Joshi, Vinit, Malamas, Michael, Zvonok, Alexander, Wood, JodiAnne, Kautz, Roger A., Strand, David, Guo, Jason J., Makriyannis, Alexandros
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556269/
https://ncbi.nlm.nih.gov/pubmed/33101030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.575691
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