Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite

Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly studied using LC-MS based approaches. However, metabolite quantities isolated...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Honrao, Chandrashekhar, Ma, Xiaoyu, Kulkarni, Shashank, Joshi, Vinit, Malamas, Michael, Zvonok, Alexander, Wood, JodiAnne, Kautz, Roger A., Strand, David, Guo, Jason J., Makriyannis, Alexandros
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556269/
https://ncbi.nlm.nih.gov/pubmed/33101030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.575691
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