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Combination of ACY-241 and JQ1 Synergistically Suppresses Metastasis of HNSCC via Regulation of MMP-2 and MMP-9

Overexpression of histone deacetylase 6 (HDAC6) and bromodomain-containing protein 4 (BRD4) is related to aggressiveness of head and neck squamous carcinoma (HNSCC). Based on studies that HDAC6 and BRD4 are potential therapeutic targets of HNSCC, we hypothesized that the combination treatment of BET...

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Podrobná bibliografie
Vydáno v:Int J Mol Sci
Hlavní autoři: Cho, Ha Young, Lee, Sang Wu, Jeon, Yu Hyun, Lee, Dong Hoon, Kim, Go Woon, Yoo, Jung, Kim, So Yeon, Kwon, So Hee
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554925/
https://ncbi.nlm.nih.gov/pubmed/32961679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186873
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