Sensing Host Arginine Is Essential for Leishmania Parasites’ Intracellular Development

Arginine homeostasis in lysosomes is critical for the growth and metabolism of mammalian cells. Phagolysosomes of macrophages are the niche where the parasitic protozoan Leishmania resides and causes human leishmaniasis. During infection, parasites encounter arginine deprivation, which is monitored...

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Vydáno v:mBio
Hlavní autoři: Goldman-Pinkovich, Adele, Kannan, Sriram, Nitzan-Koren, Roni, Puri, Madhu, Pawar, Harsh, Bar-Avraham, Yael, McDonald, Jacquelyn, Sur, Aakash, Zhang, Wen-Wei, Matlashewski, Greg, Madhubala, Rentala, Michaeli, Shulamit, Myler, Peter J., Zilberstein, Dan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554669/
https://ncbi.nlm.nih.gov/pubmed/33051367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02023-20
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