Sensing Host Arginine Is Essential for Leishmania Parasites’ Intracellular Development

Arginine homeostasis in lysosomes is critical for the growth and metabolism of mammalian cells. Phagolysosomes of macrophages are the niche where the parasitic protozoan Leishmania resides and causes human leishmaniasis. During infection, parasites encounter arginine deprivation, which is monitored...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Goldman-Pinkovich, Adele, Kannan, Sriram, Nitzan-Koren, Roni, Puri, Madhu, Pawar, Harsh, Bar-Avraham, Yael, McDonald, Jacquelyn, Sur, Aakash, Zhang, Wen-Wei, Matlashewski, Greg, Madhubala, Rentala, Michaeli, Shulamit, Myler, Peter J., Zilberstein, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554669/
https://ncbi.nlm.nih.gov/pubmed/33051367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02023-20
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