Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence

There is an urgent need to develop novel antifungals to tackle the threat fungal pathogens pose to human health. Here, we have performed a comprehensive characterization and validation of the promising target methionine synthase (MetH). We show that in Aspergillus fumigatus the absence of this enzym...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Scott, Jennifer, Sueiro-Olivares, Monica, Thornton, Benjamin P., Owens, Rebecca A., Muhamadali, Howbeer, Fortune-Grant, Rachael, Thomson, Darren, Thomas, Riba, Hollywood, Katherine, Doyle, Sean, Goodacre, Royston, Tabernero, Lydia, Bignell, Elaine, Amich, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554668/
https://ncbi.nlm.nih.gov/pubmed/33051366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01985-20
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