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Exploring the sequence fitness landscape of a bridge between protein folds

Most foldable protein sequences adopt only a single native fold. Recent protein design studies have, however, created protein sequences which fold into different structures apon changes of environment, or single point mutation, the best characterized example being the switch between the folds of the...

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Pubblicato in:PLoS Comput Biol
Autori principali: Tian, Pengfei, Best, Robert B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553338/
https://ncbi.nlm.nih.gov/pubmed/33048928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008285
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