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Exploring protein fitness landscapes by directed evolution
Directed evolution circumvents our profound ignorance of how a protein's sequence encodes its function by using iterative rounds of random mutation and artificial selection to discover new and useful proteins. Proteins can be tuned to adapt to new functions or environments via simple adaptive w...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997618/ https://ncbi.nlm.nih.gov/pubmed/19935669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm2805 |
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