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Directed enzyme evolution: climbing fitness peaks one amino acid at a time
Directed evolution can generate a remarkable range of new enzyme properties. Alternate substrate specificities and reaction selectivities are readily accessible in enzymes from families that are naturally functionally diverse. Activities on new substrates can be obtained by improving variants with b...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2703427/ https://ncbi.nlm.nih.gov/pubmed/19249235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2009.01.017 |
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