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Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid
The impressive rate accelerations that enzymes display in nature often result from boosting the inherent catalytic activities of side chains by their precise positioning inside a protein binding pocket. Such fine‐tuning is also possible for catalytic unnatural amino acids. Specifically, the directed...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6519144/ https://ncbi.nlm.nih.gov/pubmed/30575260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201813499 |
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