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Navigating the protein fitness landscape with Gaussian processes
Knowing how protein sequence maps to function (the “fitness landscape”) is critical for understanding protein evolution as well as for engineering proteins with new and useful properties. We demonstrate that the protein fitness landscape can be inferred from experimental data, using Gaussian process...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549130/ https://ncbi.nlm.nih.gov/pubmed/23277561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215251110 |
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