Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

[Image: see text] COVID-19 is a global pandemic, thus requiring multiple strategies to develop modalities against it. Herein, we designed multiple bioactive small molecules that target a functional structure within the SARS-CoV-2’s RNA genome, the causative agent of COVID-19. An analysis to characte...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Haniff, Hafeez S., Tong, Yuquan, Liu, Xiaohui, Chen, Jonathan L., Suresh, Blessy M., Andrews, Ryan J., Peterson, Jake M., O’Leary, Collin A., Benhamou, Raphael I., Moss, Walter N., Disney, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553039/
https://ncbi.nlm.nih.gov/pubmed/33140033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00984
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