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Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D(3)R Bitopic Agonists
[Image: see text] In this study, starting from our selective D(3)R agonist FOB02-04A (5), we investigated the chemical space around the linker portion of the molecule via insertion of a hydroxyl substituent and ring-expansion of the trans-cyclopropyl moiety into a trans-cyclohexyl scaffold. Moreover...
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| Publicado en: | ACS Med Chem Lett |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7549273/ https://ncbi.nlm.nih.gov/pubmed/33062179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00660 |
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