De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

[Image: see text] Nonspecific promiscuous compounds can mislead researchers and waste significant resources. This phenomenon, though well-documented for small molecules, has not been widely explored for the peptide modality. Here we demonstrate that two purported peptide-based KRas inhibitors, SAH-S...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Ng, Simon, Juang, Yu-Chi, Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Ferrer-Gago, Fernando J., Lee, Xue’Er Cheryl, Liew, Xi, Johannes, Charles W., Brown, Christopher J., Kannan, Srinivasaraghavan, Aronica, Pietro G., Berglund, Nils A., Verma, Chandra S., Liu, Lijuan, Stoeck, Alexander, Sawyer, Tomi K., Partridge, Anthony W., Lane, David P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549268/
https://ncbi.nlm.nih.gov/pubmed/33062184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00022
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