Hit selection with false discovery rate control in genome-scale RNAi screens

RNA interference (RNAi) is a modality in which small double-stranded RNA molecules (siRNAs) designed to lead to the degradation of specific mRNAs are introduced into cells or organisms. siRNA libraries have been developed in which siRNAs targeting virtually every gene in the human genome are designe...

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Bibliografiske detaljer
Main Authors: Zhang, Xiaohua Douglas, Kuan, Pei Fen, Ferrer, Marc, Shu, Xiaohua, Liu, Yingxue C., Gates, Adam T., Kunapuli, Priya, Stec, Erica M., Xu, Min, Marine, Shane D., Holder, Daniel J., Strulovici, Berta, Heyse, Joseph F., Espeseth, Amy S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504311/
https://ncbi.nlm.nih.gov/pubmed/18628291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn435
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