De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

[Image: see text] Nonspecific promiscuous compounds can mislead researchers and waste significant resources. This phenomenon, though well-documented for small molecules, has not been widely explored for the peptide modality. Here we demonstrate that two purported peptide-based KRas inhibitors, SAH-S...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Ng, Simon, Juang, Yu-Chi, Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Ferrer-Gago, Fernando J., Lee, Xue’Er Cheryl, Liew, Xi, Johannes, Charles W., Brown, Christopher J., Kannan, Srinivasaraghavan, Aronica, Pietro G., Berglund, Nils A., Verma, Chandra S., Liu, Lijuan, Stoeck, Alexander, Sawyer, Tomi K., Partridge, Anthony W., Lane, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549268/
https://ncbi.nlm.nih.gov/pubmed/33062184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00022
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