Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability

Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these molecules to be applied to targets that are typically...

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Publié dans:Chem Sci
Auteurs principaux: Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2020
Sujets:
Chemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441689/
https://ncbi.nlm.nih.gov/pubmed/32874502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc06383h
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