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A soluble derivative of PrP(C) activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor
Cellular prion protein (PrP(C)) is a widely expressed glycosylphosphatidylinositol-anchored membrane protein. Scrapie prion protein is a misfolded and aggregated form of PrP(C) responsible for prion-induced neurodegenerative diseases. Understanding the function of the nonpathogenic PrP(C) monomer is...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7549038/ https://ncbi.nlm.nih.gov/pubmed/32788217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013779 |
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