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Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs

RNAs are a promising class of therapeutics given their ability to regulate protein concentrations at the cellular level. Developing safe and effective strategies to deliver RNAs remains important for realizing their full clinical potential. Here, we develop lipid nanoparticle formulations that can d...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Kaczmarek, James C., Zeng, Manhao D., Andresen, Jason L., Rhym, Luke H., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548314/
https://ncbi.nlm.nih.gov/pubmed/30112821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201809056
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