Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF

While near-cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (<10% compared to an AUG in optimal context). Here, we describe a rare case of highly efficient near-cognate initiation. A CUG triplet located in the 5′ leader of POLG messen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Loughran, Gary, Zhdanov, Alexander V., Mikhaylova, Maria S., Rozov, Fedor N., Datskevich, Petr N., Kovalchuk, Sergey I., Serebryakova, Marina V., Kiniry, Stephen J., Michel, Audrey M., O’Connor, Patrick B. F., Papkovsky, Dmitri B., Atkins, John F., Baranov, Pavel V., Shatsky, Ivan N., Andreev, Dmitry E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547235/
https://ncbi.nlm.nih.gov/pubmed/32958672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001433117
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