Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF

While near-cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (<10% compared to an AUG in optimal context). Here, we describe a rare case of highly efficient near-cognate initiation. A CUG triplet located in the 5′ leader of POLG messen...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Loughran, Gary, Zhdanov, Alexander V., Mikhaylova, Maria S., Rozov, Fedor N., Datskevich, Petr N., Kovalchuk, Sergey I., Serebryakova, Marina V., Kiniry, Stephen J., Michel, Audrey M., O’Connor, Patrick B. F., Papkovsky, Dmitri B., Atkins, John F., Baranov, Pavel V., Shatsky, Ivan N., Andreev, Dmitry E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547235/
https://ncbi.nlm.nih.gov/pubmed/32958672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001433117
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